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Germline Variants in Indian Non-Small Cell Lung Cancer Patients With Familial Aggregation: A Prospective Cohort Study.

Clinical lung cancer - 1 Jan 2026

Agrawal Aayushi, Chitikela Sindhura Durga, Rastogi Abhay, Khurana Sachin, Pushpam Deepam, Pramanik Raja, Kumar Akash, Sharma Aparna, Chettri Monika, Gupta Ishaan, Rathore Amber, Jain Deepali, Kumar Sachin, Malik Prabhat Singh

Abstract excerpt

BACKGROUND: While smoking is a principal risk factor for lung cancer, the steadily increasing incidence in never smokers is underscoring the impact of additional factors, such as genetic predisposition. The presence of pathogenic or likely pathogenic germline variants in cancer predisposition genes has been recognized as a contributing factor to lung cancer, suggesting that familial aggregation is a pertinent...

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Carcinoma, Non-Small-Cell Lung
Follow-Up Studies
Genetic Testing
Germ-Line Mutation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

High-Throughput Nucleotide Sequencing

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PMID: 41270309
DOI: 10.1016/j.cllc.2025.10.020

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ATM
BRCA2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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