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Article

Germline testing in lung cancer: evidence of enrichment without a standardized selection strategy - a systematic review.

Lung cancer (Amsterdam, Netherlands) - 1 Sept 2026

Citarella Fabrizio, Ferrara Roberto, Di Maio Massimo, Crucitti Pierfilippo, Lintas Carla, Cascetta Priscilla, Russano Marco, Pantano Francesco, Vincenzi Bruno, Tonini Giuseppe, Gurrieri Fiorella, Cortellini Alessio

Abstract excerpt

BACKGROUND: Germline testing (GT) is increasingly integrated into oncology practice, yet its role in lung cancer (LC) remains undefined. While germline predisposition has clinical implications in several malignancies, LC is primarily driven by environmental factors and characterized by a relatively low prevalence of pathogenic germline variants (PGVs). Whether patient selection strategies may improve the...

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PMID: 42442150
DOI: 10.1016/j.lungcan.2026.109534

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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