Article
Genomic Profiles of Pathogenic and Moderate-Penetrance Germline Variants Associated With Risk of Early-Onset Lung Adenocarcinoma.
Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer - 1 Nov 2025
Cho Hourin, Shiraishi Kouya, Sunami Kuniko, Momozawa Yukihide, Yoshida Tatsuya, Matsumoto Shingo, Matsuda Koichi, Saito Motonobu, Goto Akiteru, Honda Takayuki, Mochizuki Akifumi, Torasawa Masahiro, Daigo Yataro, Shimizu Kimihiro, Kunitoh Hideo, Yoshida Yukihiro, Hirata Makoto, Shimada Yoko, Ueki Michiko, Ono Hanako, Gotoh Masahiro, Shimoda Igawa Yukiko, Tateishi Akiko, Yamaguchi Yoh, Inaba Higashiyama Ryoko, Machida Erika, Iwasaki Motoki, Kawai Yosuke, Yasuda Hiroyuki, Hamamoto Junko, Imoto Issei, Matsushita Hirokazu, Takata Sadaaki, Aoi Tomomi, Kaneko Syuzo, Kuchiba Aya, Shimomura Akihiko, Fukami Maki, Hattori Kotaro, Ozaki Kouichi, Asano Yoshihiro, Takano Atsushi, Kobayashi Masashi, Miyagi Yohei, Tanaka Kazumi, Suzuki Hiroyuki, Yamaura Takumi, Yoshida Teruhiko, Goto Yasushi, Horinouchi Hidehito, Miyazaki Yasunari, Ito Hidemi, Nagashima Toshiteru, Ohtaki Yoichi, Imai Kazuhiro, Minamiya Yoshihiro, Okubo Kenichi, Inazawa Johji, Shiraishi Yuichi, Tokunaga Katsushi, Kamatani Yoichiro, Yatabe Yasushi, Goto Koichi, Tsuboi Masahiro, Watanabe Shun-Ichi, Ohe Yuichiro, Murakami Yoshinori, Matsuo Keitaro, Hamamoto Ryuji, Kohno Takahshi
Abstract excerpt
INTRODUCTION: Up to 54% of all lung adenocarcinoma (LADC) cases in Asian populations occur in never-smoking women, suggesting that the impact of smoking and other environmental factors on the risk of early-onset LADC is minimal. Genetic factors may play a crucial role in disease development. METHODS: The prevalence of germline pathogenic variants (GPVs) of 454 hereditary cancer and DNA repair genes was evaluated...
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