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Prevalence of pathogenic or likely pathogenic germline variants in cancer predisposition genes among selected patients with lung adenocarcinoma: The GERMLUNG study.

Lung cancer (Amsterdam, Netherlands) - 1 Aug 2024

Arrieta Oscar, Caballé-Pérez Enrique, Hernández-Pedro Norma, Romero-Nuñez Eunice, Lucio-Lozada José, Castillo-Ruiz Cesar, Acevedo-Castillo Karla, María Álvarez-Gómez Rosa, Molina-Garay Carolina, Jiménez-Olivares Marco, Carrillo-Sánchez Karol, Cristina Mendoza-Caamal Elvia, Cardona Andrés F, Remon Jordi, Alaez-Verson Carmen

Abstract excerpt

INTRODUCTION: Pathogenic or likely pathogenic germline variants (PGVs) in cancer predisposition genes may play a role in lung cancer (LC) susceptibility. However, determining an eligible population for genetic testing remains uncertain. This study aimed to assess the prevalence of PGVs in a selected cohort of individuals with lung adenocarcinoma. METHODS: A cross-sectional cohort study was conducted to assess the...

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Adenocarcinoma of Lung
Checkpoint Kinase 2
Cohort Studies
Cross-Sectional Studies

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Genetic Testing

Germ-Line Mutation

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Identifiers

PMID: 38945003
DOI: 10.1016/j.lungcan.2024.107864

Genes

ATM
BRCA2
CHEK2
TP53

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