Article
The genetics of systemic lupus erythematosus and implications for targeted therapy.
Annals of the rheumatic diseases - 1 Mar 2011
Sestak Andrea L, Fürnrohr Barbara G, Harley John B, Merrill Joan T, Namjou Bahram
Abstract excerpt
Observations of familial aggregation (λs=8-29) and a 40% identical twin concordance rate prompted recent work towards a comprehensive genetic analysis of systemic lupus erythematosus (SLE). Since 2007, the number of genetic effects known to be associated with human lupus has increased by fivefold, underscoring the complexity of inheritance that probably contributes to this disease. Approximately 35 genes...
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