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Identification of pathogenic germline variants in a large Chinese lung cancer cohort by clinical sequencing.

Molecular oncology - 1 May 2024

Yu Zhe, Zhang Zirui, Liu Jun, Wu Xiaoying, Fan Xiaojun, Pang Jiaohui, Bao Hua, Yin Jiani, Wu Xue, Shao Yang, Liu Zhengcheng, Liu Fang

Abstract excerpt

Genetic factors play significant roles in the tumorigenicity of lung cancer; however, there is lack of systematic and large-scale characterization of pathogenic germline variants for lung cancer. In this study, germline variants in 146 preselected cancer-susceptibility genes were detected in 17 904 Chinese lung cancer patients by clinical next-generation sequencing. Among 17 904 patients, 1738 patients (9.7%)...

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Identifiers

PMID: 37885353
DOI: 10.1002/1878-0261.13548
PMCID: PMC11076998

Genes

SBDS
ATM
BLM
BRCA2
TSHR
BRCA1
BRIP1
MUTYH

Variants

Provenance

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