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Article

Landscape of germline pathogenic variants in patients with dual primary breast and lung cancer.

Human genomics - 17 Jul 2023

Lee Ning-Yuan, Hum Melissa, Zihara Sabna, Wang Lanying, Myint Matthew K, Lim Darren Wan-Teck, Toh Chee-Keong, Skanderup Anders, Samol Jens, Tan Min-Han, Ang Peter, Lee Soo-Chin, Tan Eng-Huat, Lai Gillianne G Y, Tan Daniel S W, Yap Yoon-Sim, Lee Ann S G

Abstract excerpt

BACKGROUND: Cancer predisposition is most often studied in the context of single cancers. However, inherited cancer predispositions can also give rise to multiple primary cancers. Yet, there is a paucity of studies on genetic predisposition in multiple primary cancers, especially those outside of well-defined cancer predisposition syndromes. This study aimed to identify germline variants associated with dual...

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Share to BRCA gene mutations in cancer
Share to Breast Neoplasms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genetic Predisposition to Disease

Share to Germ Cells

Share to Germ-Line Mutation

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Share to Lung Neoplasms

Share to Neoplasms, Multiple Primary

Source

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Identifiers

PMID: 37461096
DOI: 10.1186/s40246-023-00510-7
PMCID: PMC10353088

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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