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Article

Identification of BRCA2 Likely Germline Pathogenic Variants in Patients with Multiple Primary Lung Adenocarcinomas.

Oncology research - 1 Jan 2026

Quoc Tran Dat, Takeda Mayu, Sugihara Eiji, Tsukamoto Tetsuya, Hoshikawa Yasushi, Mizutani Yasuyoshi, Shiogama Kazuya, Asai Naoya, Niimi Atsuko, Sumitomo Makoto, Saya Hideyuki, Suzuki Motoshi

Abstract excerpt

Objectives: Genetic risk models have substantially advanced our understanding of germline pathogenic variants (GPVs) in some malignancies, whereas their clinical significance in lung cancer remains unclear. The present study aimed to better understand potential contribution of GPVs to lung cancer etiology. Methods: A targeted sequencing panel of 143 cancer-related genes was applied to analyze 26 distinct lung...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 42232598
DOI: 10.32604/or.2026.078309
PMCID: PMC13223183

Genes

BRCA2
KIT
AR
CARD11
KMT2D
NRG1
PDGFRB
TP53

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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