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Article

TP53 variants in p53 signatures and the clonality of STICs in RRSO samples.

Journal of gynecologic oncology - 1 Jul 2022

Akahane Tomoko, Masuda Kenta, Hirasawa Akira, Kobayashi Yusuke, Ueki Arisa, Kawaida Miho, Misu Kumiko, Nakamura Kohei, Nagai Shimpei, Chiyoda Tatsuyuki, Yamagami Wataru, Hayashi Shigenori, Kataoka Fumio, Banno Kouji, Sugano Kokichi, Okita Hajime, Kosaki Kenjiro, Nishihara Hiroshi, Aoki Daisuke

Abstract excerpt

OBJECTIVE: Precursor lesions may be identified in fallopian tube tissue after risk-reducing salpingo-oophorectomy (RRSO) in patients with pathogenic variants of BRCA1/2. Serous tubal intraepithelial carcinoma (STIC) is considered a precursor of high-grade serous carcinoma, whereas the significance of the p53 signature remains unclear. In this study, we investigated the relationship between the p53 signature and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 35557033
DOI: 10.3802/jgo.2022.33.e50
PMCID: PMC9250861

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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