Article
Talin-tensin3 interactions regulate fibrillar adhesion formation and tensin3 phase separation.
The Journal of cell biology - 5 Jan 2026
Li Xingchen, Konstantinou Rafaella, Meena Vinod Kumar, Notash Saba, Khalil Komal, Whalley Tom, Atherton Paul, Barsukov Igor, Zacharchenko Thomas, Ballestrem Christoph
Abstract excerpt
Integrin-mediated cell-matrix adhesions regulate communication between cells and the extracellular matrix. In matrix-secreting cells, fibrillar adhesions (FBs) containing high levels of α5β1 integrins and the tensin3 adaptor protein are essential for fibronectin (FN) fibrillogenesis. Here, we demonstrate that tensin3 binds to four helical regions (R3, R4, R8, and R11) of talin, the principal integrin activator....
Topics
- Humans
- Tensins
- Talin
- Phase Separation
- Protein Interaction Maps
- Mutation
- Fibronectins
- Integrins
- Biomolecular Condensates
- Cell-Matrix Junctions
- Binding Sites