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Article

Cell adhesion to fibrillin-1 molecules and microfibrils is mediated by alpha 5 beta 1 and alpha v beta 3 integrins.

The Journal of biological chemistry - 5 Sept 2003

Bax Daniel V, Bernard Sarah E, Lomas Amanda, Morgan Amanda, Humphries Jon, Shuttleworth C Adrian, Humphries Martin J, Kielty Cay M

Abstract excerpt

Fibrillins are the major glycoprotein components of microfibrils that form a template for tropoelastin during elastic fibrillogenesis. We have examined cell adhesion to assembled purified microfibrils, and its molecular basis. Human dermal fibroblasts exhibited Arg-Gly-Asp and cation-dependent adhesion to microfibrils and recombinant fibrillin-1 protein fragments. Strong integrin alpha 5 beta 1 interactions with...

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Identifiers

PMID: 12807887
DOI: 10.1074/jbc.M303159200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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