Fibronectin fibrils regulate TGF-β1-induced Epithelial-Mesenchymal Transition.

doi:10.1016/j.matbio.2017.01.001

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Article

Fibronectin fibrils regulate TGF-β1-induced Epithelial-Mesenchymal Transition.

Matrix biology : journal of the International Society for Matrix Biology - 1 Jul 2017

Griggs Lauren A, Hassan Nadiah T, Malik Roshni S, Griffin Brian P, Martinez Brittany A, Elmore Lynne W, Lemmon Christopher A

Abstract excerpt

Epithelial-Mesenchymal Transition (EMT) is a dynamic process through which epithelial cells transdifferentiate from an epithelial phenotype into a mesenchymal phenotype. Previous studies have demonstrated that both mechanical signaling and soluble growth factor signaling facilitate this process. One possible point of integration for mechanical and growth factor signaling is the extracellular matrix. Here we...

Topics

Animals
Antibodies, Monoclonal
Bacterial Proteins
Biomechanical Phenomena
Cell Line, Tumor
Cell Movement
Cytokines
Dogs
Epithelial Cells
Epithelial-Mesenchymal Transition

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Extracellular Matrix

Fibronectins

Gene Expression Regulation

Humans

Madin Darby Canine Kidney Cells

Mutation

Protein Binding

Signal Transduction

Source

Open in PubMed Open full text

Identifiers

PMID: 28109697
DOI: 10.1016/j.matbio.2017.01.001
PMCID: PMC5438896

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