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Article

ChemR23 prevents phenotypic switching of vascular smooth muscle cells into macrophage-like foam cells in atherosclerosis.

Cardiovascular research - 16 Mar 2026

Evans Bryce R, Schulz Julia, Triantafyllidou Vasiliki, Yerly Anais, Thakur Manovriti, Angliker Nico, Siegrist Mark, Jansen Yvonne, Yan Yi, Maas Sanne L, Gold Christoph, Farina Floriana M, Bayer Batoul, Bartelt Alexander, Weber Christian, Wettich Justus, Maegdefessel Lars, Sachs Nadia, Schindewolf Marc, Kotelis Drosos, Noels Heidi, Santovito Donato, van der Vorst Emiel P C, Döring Yvonne

Abstract excerpt

AIMS: Haematopoietic ChemR23 deficiency was shown to reduce atherosclerotic lesions by increasing M2 macrophages, but conflicting results in systemically deficient mice suggest a cell-specific function of ChemR23. Therefore, we aimed to study the role of ChemR23 particularly on vascular smooth muscle cells (VSMCs) in atherosclerosis. METHODS AND RESULTS: Mice with a non-haematopoietic cell ChemR23 deficiency due...

Topics

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Aorta
Aortic Diseases
Diet, Western
Foam Cells

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mice, Knockout, ApoE

Muscle, Smooth, Vascular

Myocytes, Smooth Muscle

Plaque, Atherosclerotic

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Identifiers

PMID: 41264461
DOI: 10.1093/cvr/cvaf258
PMCID: PMC13017563

Genes

C9

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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