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Article

ChemR23 activation reprograms macrophages toward a less inflammatory phenotype and dampens carcinoma progression.

Frontiers in immunology - 1 Jan 2023

Lavy Margot, Gauttier Vanessa, Dumont Alison, Chocteau Florian, Deshayes Sophie, Fresquet Judith, Dehame Virginie, Girault Isabelle, Trilleaud Charlène, Neyton Stéphanie, Mary Caroline, Juin Philippe, Poirier Nicolas, Barillé-Nion Sophie, Blanquart Christophe

Abstract excerpt

Introduction: Tumor Associated Macrophages (TAM) are a major component of the tumor environment and their accumulation often correlates with poor prognosis by contributing to local inflammation, inhibition of anti-tumor immune response and resistance to anticancer treatments. In this study, we thus investigated the anti-cancer therapeutic interest to target ChemR23, a receptor of the resolution of inflammation...

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Identifiers

PMID: 37539056
DOI: 10.3389/fimmu.2023.1196731
PMCID: PMC10396772

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