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Article

Proteome-wide mendelian randomization identifies therapeutic targets for nephrolithiasis.

Urolithiasis - 6 Sept 2024

Wang Li, Li Kun-Peng, Chen Si-Yu, Wan Shun, Li Xiao-Ran, Yang Li

Abstract excerpt

Kidney Stone Disease (KSD) constitutes a multifaceted disorder, emerging from a confluence of environmental and genetic determinants, and is characterized by a high frequency of occurrence and recurrence. Our objective is to elucidate potential causative proteins and identify prospective pharmacological targets within the context of KSD. This investigation harnessed the unparalleled breadth of plasma protein and...

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PMID: 39237840
DOI: 10.1007/s00240-024-01627-7

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