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In Vivo Determinants of Hepatitis C Virus Adaptation and Escape From Neutralizing Antibody AR5A.

Cellular and molecular gastroenterology and hepatology - 1 Jan 2026

Velázquez-Moctezuma Rodrigo, Burm Rani, Verhoye Lieven, Collignon Laura, Holmbeck Kenn, Giang Erick, Law Mansun, Bukh Jens, Meuleman Philip, Prentoe Jannick

Abstract excerpt

BACKGROUND & AIMS: Mechanisms of hepatitis C virus (HCV) adaptation and escape from broadly neutralizing antibodies (bNAbs) have been primarily studied in vitro. Here, we used a previously developed in vivo adapted J6/JFH1A876P virus and the highly bNAb sensitive hypervariable region 1 (HVR1) deleted variant, J6/JFH1A876P,ΔHVR1, to study adaptation and bNAb AR5A escape in the HCV-permissive human-liver chimeric...

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Share to Adaptation, Physiological
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41260569
DOI: 10.1016/j.jcmgh.2025.101684
PMCID: PMC12914401

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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