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Article

Broadly neutralizing antibodies abrogate established hepatitis C virus infection.

Science translational medicine - 17 Sept 2014

de Jong Ype P, Dorner Marcus, Mommersteeg Michiel C, Xiao Jing W, Balazs Alejandro B, Robbins Justin B, Winer Benjamin Y, Gerges Sherif, Vega Kevin, Labitt Rachael N, Donovan Bridget M, Giang Erick, Krishnan Anuradha, Chiriboga Luis, Charlton Michael R, Burton Dennis R, Baltimore David, Law Mansun, Rice Charles M, Ploss Alexander

Abstract excerpt

In most exposed individuals, hepatitis C virus (HCV) establishes a chronic infection; this long-term infection in turn contributes to the development of liver diseases such as cirrhosis and hepatocellular carcinoma. The role of antibodies directed against HCV in disease progression is poorly understood. Neutralizing antibodies (nAbs) can prevent HCV infection in vitro and in animal models. However, the effects of...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 25232181
DOI: 10.1126/scitranslmed.3009512
PMCID: PMC4312107

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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