Article
In vitro selection of a neutralization-resistant hepatitis C virus escape mutant.
Proceedings of the National Academy of Sciences of the United States of America - 9 Dec 2008
Gal-Tanamy Meital, Keck Zhen-Yong, Yi MinKyung, McKeating Jane A, Patel Arvind H, Foung Steven K H, Lemon Stanley M
Abstract excerpt
Effective immunization against hepatitis C virus (HCV) infections is likely to require the induction of both robust T and B cell immunity. Although neutralizing antibodies may play an important role in control of infection, there is little understanding of the structure of the HCV envelope glycoproteins and how they interact with such antibodies. An additional challenge for vaccine design is the genetic diversity...
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