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Article

Association of HLA-DRB1 pocket structures with susceptibility and prognosis of Graves' and Hashimoto's disease.

Endocrine journal - 2 Mar 2026

Noguchi Yusuke, Arakawa Yuya, Inoue Naoya, Inaoka Chisa, Yano Yukiko, Hidaka Yoh, Iwatani Yoshinori, Watanabe Mikio

Abstract excerpt

The physical and/or electrical properties of the peptide-binding pockets of Human Leukocyte Antigen (HLA) class II molecules vary depending on their amino acid sequence, influencing peptide-binding affinity. Previous studies have reported associations between HLA-DRB1 amino acid polymorphisms and susceptibility to Graves' disease (GD) and Hashimoto's disease (HD). We hypothesized that polymorphisms in the...

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Identifiers

PMID: 41242731
DOI: 10.1507/endocrj.EJ25-0400
PMCID: PMC12996725

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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