Article
Shared molecular amino acid signature in the HLA-DR peptide binding pocket predisposes to both autoimmune diabetes and thyroiditis.
Proceedings of the National Academy of Sciences of the United States of America - 28 Sept 2010
Menconi Francesca, Osman Roman, Monti Maria C, Greenberg David A, Concepcion Erlinda S, Tomer Yaron
Abstract excerpt
There is strong genetic association between type 1A diabetes (T1D) and autoimmune thyroid disease (AITD). T1D and AITD frequently occur together in the same individual, a condition classified as a variant of the autoimmune polyglandular syndrome type 3 (APS3). Because T1D and AITD are individually strongly associated with different HLA class II sequences, we asked which HLA class II pocket sequence and structure...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.