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Article

Association of B7H3 and B7H4 gene polymorphisms and protein expression with the development and prognosis of autoimmune thyroid diseases.

Clinical endocrinology - 1 Jul 2023

Ozaki Haruka, Inoue Naoya, Iwatani Yoshinori, Watanabe Ayano, Yamamoto Mayu, Kitahara Nozomi, Tanikawa Shohei, Noguchi Yusuke, Hidaka Yoh, Watanabe Mikio

Abstract excerpt

BACKGROUND: The prognosis of autoimmune thyroid diseases (AITDs), including Graves' disease (GD) and Hashimoto's disease (HD), varies among patients. B7-H3 and B7-H4, members of the B7 family of proteins, regulate immune response. To clarify the association of B7-H3 and B7-H4 with the pathogenesis and prognosis of AITDs, we examined the expression of the soluble and membrane form of B7-H3 and B7-H4 and genotyped...

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PMID: 37066992
DOI: 10.1111/cen.14923

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