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Critical amino acid variants in HLA-DRB1 allotypes in the development of Graves' disease and Hashimoto's thyroiditis in the Japanese population.

Human immunology - 1 Apr 2021

Katahira Masahito, Ogata Hidetada, Takashima Hiromi, Ito Takahiro, Hodai Yuichi, Miwata Tsutomu, Goto Megumi, Yamaguchi Mariko, Mizoguchi Akira, Kawakubo Mitsuhiro, Nakamura Shizuka

Abstract excerpt

The effects of amino acid variants encoded by human leukocyte antigen (HLA) class II on the development of Graves' disease (GD) and Hashimoto's thyroiditis (HT) have not been fully elucidated. We investigated the HLA-DRB1 genes of 243 GD patients and 82 HT patients in the Japanese population and compared the frequencies of HLA-DRB1 alleles and HLA-DRB1 amino acid variants between these patients and the Japanese...

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PMID: 33386169
DOI: 10.1016/j.humimm.2020.12.007

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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