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Article

Critical amino acid variations in HLA-DQB1* molecules confers susceptibility to Autoimmune Thyroid Disease in south India.

Genes and immunity - 1 Jan 2019

Ramgopal S, Rathika C, Padma Malini R, Murali V, Arun K, Balakrishnan K

Abstract excerpt

The HLA-DQB1* region exhibits complex associations with autoimmune thyroid disease (AITD). AITD patients (Hashimoto's thyroiditis, HT = 180; Graves' disease, GD = 55) and age/sex matched controls (n = 235) were genotyped for DQB1* alleles by PCR-SSP. Alleles DQB1*02:02, *06:03, *06:09, *03:02, and *03:03 showed an increased risk and *02:01, *05:02, and *06:02 showed a protection toward AITD. Multiple sequence...

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PMID: 29307887
DOI: 10.1038/s41435-017-0008-6

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