Article
Identification of independent susceptible and protective HLA alleles in Japanese autoimmune thyroid disease and their epistasis.
The Journal of clinical endocrinology and metabolism - 1 Feb 2014
Ueda Sho, Oryoji Daisuke, Yamamoto Ken, Noh Jaeduk Yoshimura, Okamura Ken, Noda Mitsuhiko, Kashiwase Koichi, Kosuga Yuka, Sekiya Kenichi, Inoue Kaori, Yamada Hisakata, Oyamada Akiko, Nishimura Yasuharu, Yoshikai Yasunobu, Ito Koichi, Sasazuki Takehiko
Abstract excerpt
BACKGROUND: Autoimmune thyroid disease (AITD) includes Graves disease (GD) and Hashimoto thyroiditis (HT), which partially share immunological features. Determining the genetic basis that distinguishes GD and HT is a key to understanding the differences between these 2 related diseases. AIM: The aims of this study were to identify HLA antigens that can explain the immunopathological difference between GD and HT...
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