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Article

Cross-tissue transcriptome-wide association and Mendelian randomization identify RALB as a susceptibility gene for breast hypertrophy.

Medicine - 14 Nov 2025

Gu Junwei, Chen Jingshuang, Hu Zujian, Luo Hua

Abstract excerpt

Breast hypertrophy is a pathological condition characterized by abnormal enlargement of the breasts due to excessive glandular and adipose tissue proliferation. It is associated with physical discomfort and reduced quality of life. However, its underlying genetic basis remains largely unexplored. We conducted a cross-tissue transcriptome-wide association study (TWAS) using the UTMOST framework, integrating...

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Identifiers

PMID: 41239602
DOI: 10.1097/MD.0000000000045872
PMCID: PMC12622666

Genes

RALB
PIP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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