Article
Refining breast cancer genetic risk and biology through multi-ancestry fine-mapping analyses of 192 risk regions.
Nature genetics - 1 Jan 2025
Jia Guochong, Chen Zhishan, Ping Jie, Cai Qiuyin, Tao Ran, Li Chao, Bauer Joshua A, Xie Yuhan, Ambs Stefan, Barnard Mollie E, Chen Yu, Choi Ji-Yeob, Gao Yu-Tang, Garcia-Closas Montserrat, Gu Jian, Hu Jennifer J, Iwasaki Motoki, John Esther M, Kweon Sun-Seog, Li Christopher I, Matsuda Koichi, Matsuo Keitaro, Nathanson Katherine L, Nemesure Barbara, Olopade Olufunmilayo I, Pal Tuya, Park Sue K, Park Boyoung, Press Michael F, Sanderson Maureen, Sandler Dale P, Shen Chen-Yang, Troester Melissa A, Yao Song, Zheng Ying, Ahearn Thomas, Brewster Abenaa M, Falusi Adeyinka, Hennis Anselm J M, Ito Hidemi, Kubo Michiaki, Lee Eun-Sook, Makumbi Timothy, Ndom Paul, Noh Dong-Young, O'Brien Katie M, Ojengbede Oladosu, Olshan Andrew F, Park Min-Ho, Reid Sonya, Yamaji Taiki, Zirpoli Gary, Butler Ebonee N, Huang Maosheng, Low Siew-Kee, Obafunwa John, Weinberg Clarice R, Zhang Haoyu, Zhao Hongyu, Cote Michelle L, Ambrosone Christine B, Huo Dezheng, Li Bingshan, Kang Daehee, Palmer Julie R, Shu Xiao-Ou, Haiman Christopher A, Guo Xingyi, Long Jirong, Zheng Wei
Abstract excerpt
Genome-wide association studies have identified approximately 200 genetic risk loci for breast cancer, but the causal variants and target genes are mostly unknown. We sought to fine-map all known breast cancer risk loci using genome-wide association study data from 172,737 female breast cancer cases and 242,009 controls of African, Asian and European ancestry. We identified 332 independent association signals for...
Topics
- Female
- Humans
- Asian People