Distinct genetic profiles of obesity have different effects on breast cancer risk: leveraging Mendelian randomisation to interrogate causal pathways and identify mediating proteins.

Abstract excerpt

BACKGROUND: Obesity is a well-established risk factor for many cancers, but its association with breast cancer remains inconsistent. Obesity is a highly complex and polygenic condition, driven by multiple biological pathways, some of which have been linked to beneficial health effects, defining a metabolically healthy obese phenotype. We hypothesise that this heterogeneity may partly underlie the variable...

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