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Article

Causal relationship and pathogenic mechanism analysis of breast cancer and coronary heart disease based on mendelian randomization and transcriptome data analysis.

Immunogenetics - 13 Jul 2026

Xie Mingbin, Wu Yuanhong, Jin Xinyao, Jiang Fengchun, Yao Qiang

Abstract excerpt

Breast cancer (BC) is closely linked to coronary heart disease (CHD), yet the genetic causal relationship and common driving mechanism between the two have not been fully elucidated. The purpose of this study is to infer the causal relationship between BC and CHD at the genetic level and identify the cross-omic molecular characteristics of them through the integrated analysis of multiple genomics. Firstly,...

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Identifiers

PMID: 42437780
DOI: 10.1007/s00251-026-01411-4

Genes

HES1
HSPBP1
STARD3
TRIB3
MLPH

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

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