A multi-stage genome-wide association study of uterine fibroids in African Americans.

doi:10.1007/s00439-017-1836-1

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A multi-stage genome-wide association study of uterine fibroids in African Americans.

Human genetics - 1 Oct 2017

Hellwege Jacklyn N, Jeff Janina M, Wise Lauren A, Gallagher C Scott, Wellons Melissa, Hartmann Katherine E, Jones Sarah F, Torstenson Eric S, Dickinson Scott, Ruiz-Narváez Edward A, Rohland Nadin, Allen Alexander, Reich David, Tandon Arti, Pasaniuc Bogdan, Mancuso Nicholas, Im Hae Kyung, Hinds David A, Palmer Julie R, Rosenberg Lynn, Denny Joshua C, Roden Dan M, Stewart Elizabeth A, Morton Cynthia C, Kenny Eimear E, Edwards Todd L, Velez Edwards Digna R

Abstract excerpt

Uterine fibroids are benign tumors of the uterus affecting up to 77% of women by menopause. They are the leading indication for hysterectomy, and account for $34 billion annually in the United States. Race/ethnicity and age are the strongest known risk factors. African American (AA) women have higher prevalence, earlier onset, and larger and more numerous fibroids than European American women. We conducted a...

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PMID: 28836065
DOI: 10.1007/s00439-017-1836-1
PMCID: PMC5628188

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CYTH4

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