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Article

Live-attenuated influenza virus vaccine strain with an engineered temperature-sensitive and genetically stable viral polymerase variant.

Journal of virology - 23 Dec 2025

Naito Tadasuke, Ushirogawa Hiroshi, Kunishio Miyuki, Yano Haruka, Saito Susumu, Higeuchi Taisei, Fujita Kazuki, Saito Mineki

Abstract excerpt

Vaccination against seasonal influenza is considered an effective means of reducing morbidity and mortality. Live-attenuated vaccines offer more protection against influenza than inactivated vaccines as they efficiently induce cellular immunity and provide cross-immunogenicity against various antigenic subtypes. For the production of safer live-attenuated vaccines, it is important to develop a common master donor...

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Identifiers

PMID: 41231009
DOI: 10.1128/jvi.01390-25
PMCID: PMC12724131

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