Article
Comparative Study of the Temperature Sensitive, Cold Adapted and Attenuated Mutations Present in the Master Donor Viruses of the Two Commercial Human Live Attenuated Influenza Vaccines.
Viruses - 10 Oct 2019
Rodriguez Laura, Blanco-Lobo Pilar, Reilly Emma C, Maehigashi Tatsuya, Nogales Aitor, Smith Andrew, Topham David J, Dewhurst Stephen, Kim Baek, Martínez-Sobrido Luis
Abstract excerpt
Influenza viruses cause annual, seasonal infection across the globe. Vaccination represents the most effective strategy to prevent such infections and/or to reduce viral disease. Two major types of influenza vaccines are approved for human use: inactivated influenza vaccines (IIVs) and live attenuated influenza vaccines (LAIVs). Two Master Donor Virus (MDV) backbones have been used to create LAIVs against...
Topics
- Animals
- Dogs
- HEK293 Cells
- Humans
- Immunity, Cellular
- Immunity, Humoral
- Immunogenicity, Vaccine
- Influenza A Virus, H1N1 Subtype
- Influenza Vaccines
- Influenza, Human
- Madin Darby Canine Kidney Cells
- Mutation