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Article

Development of a Genetically Stable Live Attenuated Influenza Vaccine Strain Using an Engineered High-Fidelity Viral Polymerase.

Journal of virology - 24 May 2021

Mori Kotaro, Ohniwa Ryosuke L, Takizawa Naoki, Naito Tadasuke, Saito Mineki

Abstract excerpt

RNA viruses demonstrate a vast range of variants, called quasispecies, due to error-prone replication by viral RNA-dependent RNA polymerase. Although live attenuated vaccines are effective in preventing RNA virus infection, there is a risk of reversal to virulence after their administration. To test the hypothesis that high-fidelity viral polymerase reduces the diversity of influenza virus quasispecies, resulting...

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Identifiers

PMID: 33827947
DOI: 10.1128/JVI.00493-21
PMCID: PMC8316084

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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