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A single amino acid substitution in PB1 of pandemic H1N1 with A/Ann Arbor/6/60 master donor virus mutations as a novel live-attenuated influenza virus vaccine

2022-01-09

Abstract excerpt

<h4>ABSTRACT</h4> Influenza A viruses (IAV) remain emerging threats to human public health. Live-attenuated influenza vaccines (LAIV) are one of the most effective prophylactic options to prevent disease caused by influenza infections. However, licensed LAIV remain restricted for use in 2- to 49-year old healthy and non-pregnant people. Therefore, development of LAIV with increased safety, immunogenicity, and pro...

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Literature Corpus work: f17a32f7-53b6-5193-8782-d0ac7b2f3b94
DOI: 10.1101/2022.01.07.475442

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