Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mutation L319Q in the PB1 Polymerase Subunit Improves Attenuation of a Candidate Live-Attenuated Influenza A Virus Vaccine.

Microbiology spectrum - 29 Jun 2022

Nogales Aitor, Steel John, Liu Wen-Chun, Lowen Anice C, Rodriguez Laura, Chiem Kevin, Cox Andrew, García-Sastre Adolfo, Albrecht Randy A, Dewhurst Stephen, Martínez-Sobrido Luis

Abstract excerpt

Influenza A viruses (IAV) remain emerging threats to human public health. Live-attenuated influenza vaccines (LAIV) are one of the most effective prophylactic options to prevent disease caused by influenza infections. However, licensed LAIV remain restricted for use in 2- to 49-year-old healthy and nonpregnant people. Therefore, development of LAIV with increased safety, immunogenicity, and protective efficacy is...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Ferrets
Share to Guinea Pigs

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Influenza A virus

Share to Influenza A Virus, H1N1 Subtype

Share to Influenza, Human

Share to Influenza Vaccines

Share to Orthomyxoviridae Infections

Share to Vaccines, Attenuated

Source

Open in PubMed Open full text

Identifiers

PMID: 35583364
DOI: 10.1128/spectrum.00078-22
PMCID: PMC9241597

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mutation L319Q in the PB1 Polymerase Subunit Improves Attenuation of a Candidate Live-Attenuated Influenza A Virus Vaccine.PMID 35583364Read ↗

A single amino acid substitution in PB1 of pandemic H1N1 with A/Ann Arbor/6/60 master donor virus mutations as a novel live-attenuated influenza virus vaccineSemantic proximity Read ↗

Live-attenuated influenza virus vaccine strain with an engineered temperature-sensitive and genetically stable viral polymerase variant.Semantic proximity Read ↗

A Mutated PB1 Residue 319 Synergizes with the PB2 N265S Mutation of the Live Attenuated Influenza Vaccine to Convey Temperature Sensitivity.Semantic proximity Read ↗

Immunogenicity and protective efficacy of a live attenuated vaccine against the 2009 pandemic A H1N1 in mice and ferrets.Semantic proximity Read ↗

Mutation E48K in PB1 Polymerase Subunit Improves Stability of a Candidate Live Attenuated Influenza B Virus VaccineSemantic proximity Read ↗

Mutations in polymerase genes enhanced the virulence of 2009 pandemic H1N1 influenza virus in mice.Semantic proximity Read ↗

The PB2-E627K Mutation Attenuates Viruses Containing the 2009 H1N1 Influenza Pandemic PolymeraseSemantic proximity Read ↗

Reversion of Cold-Adapted Live Attenuated Influenza Vaccine into a Pathogenic VirusSemantic proximity Read ↗

Alternative Live-Attenuated Influenza Vaccines Based on Modifications in the Polymerase Genes Protect against Epidemic and Pandemic FluSemantic proximity Read ↗

Live attenuated influenza A virus vaccines with modified NS1 proteins for veterinary useSemantic proximity Read ↗

Modifications in the Polymerase Genes of a Swine-Like Triple-Reassortant Influenza Virus To Generate Live Attenuated Vaccines against 2009 Pandemic H1N1 VirusesSemantic proximity Read ↗

Comparative Study of the Temperature Sensitive, Cold Adapted and Attenuated Mutations Present in the Master Donor Viruses of the Two Commercial Human Live Attenuated Influenza Vaccines.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.