Truncated APC impairs innate immune response by targeting MAVS on mitochondria in colorectal cancer.

Abstract excerpt

BACKGROUND: Most mutant adenomatous polyposis coli (APC) gene produced truncated APC protein (Trunc-APC), which has been shown to function as an oncogene in colorectal cancer (CRC) pathogenesis; however, its role in modulating innate immune responses within tumor cells remains unexplored. METHODS: We utilized CRISPR-Cas9 to knockout mutant APC and performed transcriptome sequencing across multiple CRC cell lines...

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• Adenomatous Polyposis Coli Protein
• Azacitidine
• DEAD Box Protein 58
• Gene Knockout Techniques
• Hydroxamic Acids