Type I interferon remodels lysosome function and modifies intestinal epithelial defense

Abstract excerpt

Significance Here, a genome-scale CRISPR/Cas9 screen in epithelial cells using Salmonella , a prototypical intracellular pathogen, led to the discovery of a new role for IFN-I signaling. We found that this canonical antiviral signaling pathway controls the subcellular localization, protein content, pH, and protease activity of lysosomes. IFN-I signaling-dependent lysosomal acidification was associated with...

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