Article
Regulation of tubular recycling endosome biogenesis by the p53-MICALL1 pathway.
International journal of oncology - 1 Aug 2017
Takahashi Yukie, Tanikawa Chizu, Miyamoto Takafumi, Hirata Makoto, Wang Guanxiong, Ueda Koji, Komatsu Tsunehiko, Matsuda Koichi
Abstract excerpt
p53, one of the most frequently mutated genes in colon cancer, suppresses cancer development through transactivation of its targets. Herein, we conducted a comprehensive analysis of the p53 downstream pathway in colorectal cancer by using multi-omics analysis. Mass spectrometric analysis of HCT116 p53+/+ and HCT116 p53-/- cells treated with adriamycin identified 124 proteins increased by DNA damage in a...
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