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ZMYM3 mutations modulate histone acetylation and cooperate with NOTCH1 mutations in chronic lymphocytic leukemia

2025-10-29

Abstract excerpt

<title>Abstract</title> <p> Next-generation sequencing (NGS) studies have identified > 200 potential genetic drivers of chronic lymphocytic leukemia (CLL). Nevertheless, the prognostic and functional impact of numerous mutations remains elusive. Here, we assessed the clinical and biological implications of <italic>ZMYM3</italic> mutations in CLL, a gene recurrently mutated in 2–4% of patients. NGS analyses of...

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Literature Corpus work
20ce15e1-8b09-5df9-b70f-52094f9ce725
DOI
10.21203/rs.3.rs-7849174/v1
Open publication

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ZMYM3 mutations modulate histone acetylation and cooperate with NOTCH1 mutations in chronic lymphocytic leukemiaDOI 10.21203/rs.3.rs-7849174/v1
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