Long-term Benefit of PD-L1 Blockade in Lung Cancer Associated with JAK3 Activation.

doi:10.1158/2326-6066.CIR-15-0024

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Article

Long-term Benefit of PD-L1 Blockade in Lung Cancer Associated with JAK3 Activation.

Cancer immunology research - 1 Aug 2015

Van Allen Eliezer M, Golay Hadrien G, Liu Yan, Koyama Shohei, Wong Karrie, Taylor-Weiner Amaro, Giannakis Marios, Harden Maegan, Rojas-Rudilla Vanesa, Chevalier Aaron, Thai Tran, Lydon Christine, Mach Stacy, Avila Ada G, Wong Joshua A, Rabin Alexandra R, Helmkamp Joshua, Sholl Lynette, Carter Scott L, Oxnard Geoffrey, Janne Pasi, Getz Gad, Lindeman Neal, Hammerman Peter S, Garraway Levi A, Hodi F Stephen, Rodig Scott J, Dranoff Glenn, Wong Kwok-Kin, Barbie David A

Abstract excerpt

PD-1 immune checkpoint blockade occasionally results in durable clinical responses in advanced metastatic cancers. However, mechanism-based predictors of response to this immunotherapy remain incompletely characterized. We performed comprehensive genomic profiling on a tumor and germline sample from a patient with refractory lung adenocarcinoma who achieved marked long-term clinical benefit from anti-PD-L1...

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Identifiers

PMID: 26014096
DOI: 10.1158/2326-6066.CIR-15-0024
PMCID: PMC4527885

Genes

JAK3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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