Article
Lynch syndrome-associated urothelial carcinoma: clinical and molecular findings from a single-institution cohort.
Familial cancer - 2 Sept 2026
Rametta A, Barella M, Scardino A, Barbetta F, Tamborini E, Perrone F, Busico A, Agnelli L, Rota S, Gusmaroli E, Stellato M, Nuzzo A, Guadalupi V, Claps M, Ricci M T, Procopio G, Pruneri G, Milione M, Giannatempo P, Vitellaro M
Abstract excerpt
Lynch syndrome-associated urothelial carcinoma (LS-UC) is a rare and undercharacterized clinical entity. While FGFR3 alterations are well described in sporadic urothelial carcinoma, their prevalence and clinical implications in LS-UC remain unclear. We aimed to provide a comprehensive clinical and molecular characterization of LS-UC. We conducted a retrospective single-center study including patients with Lynch...
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- Humans
- Receptor, Fibroblast Growth Factor, Type 3
- Colorectal Neoplasms, Hereditary Nonpolyposis
- Female
- Male