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Article

Causal association between iron status and heart failure: A 2-sample bidirectional Mendelian randomization study.

Medicine - 7 Nov 2025

Hu Yaqi, He Tao, Liu Jianhe, Wang Weisong

Abstract excerpt

Observational studies have shown that serum iron status is related to heart failure (HF). However, due to confounding factors and reverse causation, there is still controversy over whether this association is causal. Our aim is to assess the causal relationship between genetically predicted serum iron status and HF. This study uses inverse variance weighting as the main method for Mendelian Randomization (MR)...

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Identifiers

PMID: 41204461
DOI: 10.1097/MD.0000000000045391
PMCID: PMC12599760

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