Causal relationships between metabolic-associated fatty liver disease and iron status: Two-sample Mendelian randomization.

doi:10.1111/liv.15455

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Article

Causal relationships between metabolic-associated fatty liver disease and iron status: Two-sample Mendelian randomization.

Liver international : official journal of the International Association for the Study of the Liver - 1 Dec 2022

He He, Liao Shenling, Zeng Yuping, Liang Libo, Chen Jie, Tao Chuanmin

Abstract excerpt

BACKGROUND & AIMS: Dysregulated iron homeostasis plays an important role in the hepatic manifestation of metabolic-associated fatty liver disease (MAFLD). We investigated the causal effects of five iron metabolism markers, regular iron supplementation and MAFLD risk. METHODS: Genetic summary statistics were obtained from open genome-wide association study databases. Two-sample bidirectional Mendelian...

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