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Article

Causal effects between atrial fibrillation and heart failure: evidence from a bidirectional Mendelian randomization study.

BMC medical genomics - 14 Aug 2023

Zhang Zhuxin, Li Le, Hu Zhao, Zhou Likun, Zhang Zhenhao, Xiong Yulong, Yao Yan

Abstract excerpt

BACKGROUND: Observational studies have suggested a close association between atrial fibrillation (AF) and heart failure (HF), yet the causal effect remains uncertain. In this study, we employed a bidirectional Mendelian randomization analysis to investigate the causal effect of one disease on the other. METHODS: Genetic instrumental variables were obtained from large-scale summary-level genome-wide association...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 37580781
DOI: 10.1186/s12920-023-01606-8
PMCID: PMC10424396

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