Intracellular trafficking SNARE protein, syntaxin-6, modifies prion cellular phenotypes and risk of disease development in vivo.

doi:10.1007/s00401-025-02946-8

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Intracellular trafficking SNARE protein, syntaxin-6, modifies prion cellular phenotypes and risk of disease development in vivo.

Acta neuropathologica - 4 Nov 2025

Hill Elizabeth, Patel Mitali M, Ribes Juan M, Linehan Jacqueline, Zhang Fuquan, Jakubcova Tatiana, Hamdan Shyma, Tomlinson Andrew, Ercolani Tiziana, Schmidt Christian, Ahmed Parvin, Thirlway George, Argentina Fabio, Marinho Aline T, Jones Emma, Kaye Nicholas, Fitzhugh Craig, Jackson Graham S, Brandner Sebastian, Klöhn Peter-Christian, Collinge John, Cunningham Thomas J, Mead Simon

Abstract excerpt

Increased expression of syntaxin-6, a SNARE protein involved in intracellular protein trafficking, is a proposed genetic risk mechanism for sporadic prion disease and progressive supranuclear palsy, as well as being implicated in Alzheimer's disease. However, no study has validated its functional role in prion disease, its mechanism of action nor explored the disease stage at which it is acting. Here, we show...

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PMID: 41186731
DOI: 10.1007/s00401-025-02946-8
PMCID: PMC12586215

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