Article

Genome-wide association study identifies risk variants for sporadic Creutzfeldt-Jakob disease in <i>STX6</i> and <i>GAL3ST1</i>

2020-04-11

Abstract excerpt

Mammalian prions are lethal pathogens composed of fibrillar assemblies of misfolded prion protein. Human prion diseases are rare and usually rapidly fatal neurodegenerative disorders, the most common being sporadic Creutzfeldt-Jakob disease (sCJD). Variants in the gene that encodes prion protein ( PRNP ) are strong risk factors for sCJD, but although the condition has heritability similar to other neurodegenerativ...

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Literature Corpus work: 15e9ebbc-d332-58ec-acff-29c9ebdfeab9
DOI: 10.1101/2020.04.06.20055376

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