Article

Syntaxin-6 delays prion protein fibril formation and prolongs presence of toxic aggregation intermediates

2022-08-25

Abstract excerpt

Prions replicate via the autocatalytic conversion of cellular prion protein (PrPC) into fibrillar assemblies of misfolded PrP. While this process has been extensively studied in vivo and in vitro, non-physiological reaction conditions of fibril formation in vitro have precluded the identification and mechanistic analysis of cellular proteins, which may alter PrP self-assembly and prion replication. Here, we have d...

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Literature Corpus work: 3ffeb88e-22d0-5fdc-b6d7-8585c81f9c08
DOI: 10.1101/2022.08.25.505283

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