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Characterisation and prion transmission study in mice with genetic reduction of sporadic Creutzfeldt-Jakob Disease risk gene <i>Stx6</i>

2023-01-10

Abstract excerpt

Sporadic Creutzfeldt-Jakob disease (sCJD), the most common human prion disease, is thought to occur when the cellular prion protein (PrP C ) spontaneously misfolds and assembles into prion fibrils, culminating in fatal neurodegeneration. In a genome-wide association study of sCJD, we recently identified risk variants in and around the gene STX6 , with evidence to suggest a causal increase of STX6 expression in...

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Literature Corpus work
0c8b1752-39c2-5295-96dd-6ca9d015ff60
DOI
10.1101/2023.01.10.523281
Open publication

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Characterisation and prion transmission study in mice with genetic reduction of sporadic Creutzfeldt-Jakob Disease risk gene <i>Stx6</i>DOI 10.1101/2023.01.10.523281
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