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Article

Sex-dependent behavioral responses and phenotypic traits of Pcsk9 knockout mice in anxiety- and depression-like paradigms.

Psychoneuroendocrinology - 1 Jan 2026

Nasini Sofia, Barzon Benedetta, Tidei Sara, Rossi Ilaria, Lupo Maria Giovanna, Ferri Nicola, Comai Stefano

Abstract excerpt

Proprotein Convertase Subtilisin/Kexin type 9 (PCSK9) regulates plasma LDL cholesterol by promoting the degradation of LDL receptors. Beyond lipid metabolism, PCSK9 has been implicated in neuropsychiatric conditions, including depression and anxiety, potentially through mechanisms involving inflammation, insulin resistance, and hormonal regulation. This preclinical study investigated the effects of Pcsk9...

Read the complete abstract on PubMed

Topics

Animals
Female
Male
Proprotein Convertase 9
Anxiety
Mice, Knockout
Depression

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Mice

Mice, Inbred C57BL

Behavior, Animal

Corticosterone

Disease Models, Animal

Estrous Cycle

Sex Factors

Phenotype

Exploratory Behavior

Sex Characteristics

Source

Identifiers

PMID: 41176903
DOI: 10.1016/j.psyneuen.2025.107660

Genes

PCSK9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 25 Oct 2026.

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