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Article

A novel mutation in the mouse Pcsk1 gene showing obesity and diabetes.

Mammalian genome : official journal of the International Mammalian Genome Society - 1 Feb 2020

Muhsin Nor I A, Bentley Liz, Bai Ying, Goldsworthy Michelle, Cox Roger D

Abstract excerpt

The proprotein convertase subtilisin/Kexin type 1 (PCSK1/PC1) protein processes inactive pro-hormone precursors into biologically active hormones in a number of neuroendocrine and endocrine cell types. Patients with recessive mutations in PCSK1 exhibit a complex spectrum of traits including obesity, diarrhoea and endocrine disorders. We describe here a new mouse model with a point mutation in the Pcsk1 gene that...

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Source

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Identifiers

PMID: 31974728
DOI: 10.1007/s00335-020-09826-4
PMCID: PMC7060156

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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