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Article

Impact of Fkbp5 × early life adversity × sex in humanised mice on multidimensional stress responses and circadian rhythmicity.

Molecular psychiatry - 1 Aug 2022

Nold Verena, Portenhauser Michelle, Del Prete Dolores, Blasius Andrea, Harris Isabella, Koros Eliza, Peleh Tatiana, Hengerer Bastian, Kolassa Iris-Tatjana, Slezak Michal, Allers Kelly Ann

Abstract excerpt

The cumulative load of genetic predisposition, early life adversity (ELA) and lifestyle shapes the prevalence of psychiatric disorders. Single nucleotide polymorphisms (SNPs) in the human FKBP5 gene were shown to modulate disease risk. To enable investigation of disease-related SNPs in behaviourally relevant context, we generated humanised mouse lines carrying either the risk (AT) or the resiliency (CG) allele of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 35449298
DOI: 10.1038/s41380-022-01549-z
PMCID: PMC9708571

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